It is the second largest hospital in the province of Limburg, after the Ziekenhuis Oost-Limburg with its main campus in Genk.

[3] The name Jessa is derived from the hospital's 3 care campuses: JE from Virga Jesse, S from Saint-Ursula, and SA from Salvator.

Since 1994, the new monastery complex behind it has provided a residential and care center for dementia and Alzheimer's patients.

[7] In January 2001, the Sint-Franciscusziekenhuis of Heusden-Zolder and the hospitals AZ Salvator-Saint-Ursula with campuses in Hasselt and Herk-de-Stad announced that they had concluded a merger agreement and would henceforth be called the Christian General Hospital Mid-Limburg (Dutch: Christelijk Algemeen Ziekenhuis Midden-Limburg or C.A.Z.

Without realizing it, the three nuns lay the foundation of what will be a large and modern hospital almost four hundred years later.

[10] The first postwar Commission of Public Assistance (the predecessor of the OCMW) took office in 1947 and immediately made the decision in principle to build a new hospital.

On 17 March 1995 the Limburg Oncological Center (LOC) officially opened its doors in the hospital's new L-wing.

In the year 2000, the Virga Jesse Hospital spun off from the OCMW and became an autonomous care institution.

The highest managing body of the hospital is no longer the OCMW council, but rather a general assembly and a board of directors, including a representation of the political parties.

The dossier for the new building was co-developed by a temporary association consisting of four partner architects: Osar, Baumschlager & Eberle, Technum and De Gregorio.

From the towers, patients and visitors to the hospital will have a view of Haspengouw on one side and a new park on the Salvator Campus that runs down to Hasselt's major ring road.