He co-wrote the screenplay for the Pixar film Luca and wrote both the novel and the feature-film adaptation of Me and Earl and the Dying Girl.

Andrews was born and raised in Pittsburgh, Pennsylvania, and is a graduate of both Schenley High School and Harvard University.

[4] Andrews's debut novel, Me and Earl and the Dying Girl, was published by Harry Abrams in 2012 and won that year's Cybils Award for Young Adult Fiction.

[7] In 2022, The Haters was listed among 52 novels banned by the Alpine School District following the implementation of Utah law H.B.

More recently, Andrews wrote the screenplay and story for Pixar's 2021 animated film Luca, with Mike Jones.