Jesse Grupper (/ˈɡruːpər/ GROO-pər; born January 6, 1997)[1] is an American Olympic rock climber who specializes in competition climbing.

[6] Ruth and Edward Grupper, his grandparents, assisted in founding the Rockland County, New York, New City Jewish Center Conservative synagogue.

[6] He was diagnosed as a teenager with ulcerative colitis, an incurable inflammatory bowel disease; Grupper receives a medical infusion for the condition every eight weeks, and follows a gluten-free diet.

[7][8][6] In January 2021, he was in the hospital for a week after his medication stopped working, and he had a colitis flare-up; his father said that the incident brought Grupper to "death's door".

[8] After graduating, Grupper worked on human performance for a period of time at the Boston, Massachusetts, bio-design firm Harvard Biodesign Lab, developing exoskeletons for stroke victims to restore their movement.

[20] He took the gold medal in the 2023 Pan American Games in Santiago, Chile, in the combined boulder and lead climbing discipline, thus qualifying for the 2024 Olympics.