[6] Introduced by the duo Sin Bandera at the 2005 Mexican Teletón,[7] Jesse & Joy released their debut album Esta Es Mi Vida in 2006 through Warner Music Mexico.

Additionally, together with Carlos López Estrada they received the Latin Grammy Award for Best Short Form Music Video for directing "Me Voy".

The album, produced by Fraser T Smith and Martin Terefe (Jason Mraz, James Morrison, and Shawn Mendes), included the song, "Un Besito Mas", which Jesse & Joy wrote after their father's death and is depicted in the video highlighting the US immigration issues.

[18] The Independent in the UK described album opener "Echoes of Love" as “true to their Latin/folk roots while introducing distinctly Adele-style epicness to the vocals”.

[24][25] With their live Un Besito Más Tour, Jesse & Joy visited more than 15 countries and nearly 100 cities, including Buenos Aires, Madrid, Barcelona, Santiago de Chile, New York and Los Angeles.

[14] The two artists signed a deal with Kobalt Music for their worldwide publishing beginning with their 2018 single, "Te Esperé".

[30] In April 2019, Jesse & Joy collaborated with Colombian singer J Balvin for the single, "Mañana es Too Late.” The song was written by the duo, along with Poo Bear (who has worked with David Guetta, Matoma, Justin Bieber, Mariah Carey, Skrillex, Juanes, Jennifer Lopez, Fifth Harmony) and produced by Jesse and Charlie Heat (Kanye West, Madonna).

[33] Joy was recognized by the Latin Recording Academy as one at the Leading Ladies of Entertainment at a gala June 2019 that took place in Mexico City.

The honor, for Latinas who "during their lives have demonstrated enthusiasm, determination, leadership, pride in their roots and an indomitable spirit in continuous form,"[34] that included Tatiana Bilboa, Martha de Bayle, Alondra de la Parra, and Soumaya Slim Domit.

[40] In the beginning of 2019, Joy publicly came out as pansexual and announced she had been married to her wife, Diana Atri, for 7 years.

[44] Jesse & Joy maintain an ongoing partnership with UnidosUS (formerly NCLR), the Hispanic civil rights and advocacy organization, and their “Electrify The Vote!".

[4][46] The Grammy Award is an accolade by the National Academy of Recording Arts and Sciences of the United States to recognize outstanding achievement on the music industry.