For the special, Holmes received a Gemini nomination as well as the Platinum Award at the Houston International Comedy Festival.

Holmes performed in the American films Citizen Duane and Welcome to Mooseport; and the television series Zoe Busiek: Wildcard.

That was followed by a few guest spots on Royal Canadian Air Farce, where she was invited to become the first "added" cast member since the show began 11 years earlier.

On both The Holmes Show and Air Farce, she became well known for performing caricatures of various celebrities, including Celine Dion, Liza Minnelli, Geri Halliwell, and Britney Spears.

On stage, Holmes has appeared in several Ross Petty's annual Christmas pantomime family musicals at the Toronto's Elgin Theatre, including Robin Hood, Wizard Of Oz, and Peter Pan.

As a comedian, Holmes has opened for Ellen DeGeneres, Russell Peters, Jerry Seinfeld, and Leslie Nielsen.

She has performed them for companies like Toronto Hydro, Deloitte, Eli Lilly, Credit Institute of Canada, TD, RBC, Scottsdale Insurance, Goodlife Fitness, Prudential Financial, Pepsico, Walmart, Sun Life, Lindt & Sprüngli, Comcast, and Remax.

As a speaker, she strives to help end the stigma around mental illness and in 2018 joined the Bell Let’s Talk team as a celebrity ambassador.