At the time of its closure in 2001, it was managed by the Central Sheffield University Hospitals NHS Trust.

Following a large donation by Thomas Jessop, a wealthy steelworks owner, a new building was commissioned to replace the old Sheffield Hospital for Women at Figtree Lane, which had only six beds.

[3] The hospital was in the news in 1998 when Diane Blood gave birth to a baby boy, having been inseminated using her husband's sperm, which had been taken from his body while he was unconscious on life support, shortly before his death.

[5] In 2007 the majority of the 1970s wing was demolished by the University of Sheffield as part of their Jessop West development.

[8] Demolition was pursued in favour of renovation as it provided the University of Sheffield with a greater floor area for new development at a lower cost.