The interchange is now owned by Network Rail and operated by Northern, with additional services provided by TransPennine Express.

Upon opening in 1990, Meadowhall Interchange effectively replaced Brightside station, located around one mile further down the line towards Sheffield.

In 1989, the South Yorkshire Passenger Transport Executive received a European Regional Development Fund grant for 50% of the cost of Meadowhall Interchange.

The section of line from Meadowhall to Fitzalan Square, in the city centre, was the first phase of the network to open.

[6][7] As part of the plans for High Speed 2, proposals were put forward for the construction of a new Supertram line from Meadowhall Interchange to Dore & Totley station in the south-west of the city.

The ticket office for National Rail services is located off to the side of the footbridge which connects the interchange with the shopping centre.

A second concourse is located next to the bus and coach station and contains toilets, Travel South Yorkshire ticket purchasing facilities and a number of small shopping outlets.

There are a total of sixteen stands at the bus and coach station, arranged into four main rows, each accessed by zebra crossings.

Until 25 October 2018, additional services were provided by the Purple route on Sundays, and prior to 2016, during off-peak hours of operation during the week and on Saturdays.