Jesuit College, Messina (Italian: Collegio dei gesuiti), with the adjacent church of San Giovanni Battista of the Society of Jesus had been an important building complex in the city of Messina, Sicily, Italy.

[1] At the insistence of Juan de Vega, Viceroy of Sicily, Ignatius of Loyola agreed to open a college there, the very first college founded by the Jesuits and for this reason known as "Primum ac Prototypum Collegium".

Since this gave new direction to the apostolic options of the Society of Jesus, Ignatius added solemnity to its founding, requesting the Pope's blessing for the opening team of ten Jesuits which included one of his earliest companions Jerome Nadal.

[citation needed] Early Jesuit library inventories provide an idea of topics studied.

Only the entrance portal with four columns was kept as part of the complex of buildings of the new University of Messina, built on the site of the former college.