The Jevišovka originates in the territory of Komárovice in the Křižanov Highlands at an elevation of 557 m (1,827 ft) and flows to Jevišovka, where it enters the Thaya River at an elevation of 175 m (574 ft).

Its drainage basin has an area of 787.1 km2 (303.9 sq mi).

The most populous town on the river is Hrušovany nad Jevišovkou.

The river flows through the municipal territories of Komárovice, Moravské Budějovice, Nové Syrovice, Častohostice, Blížkovice, Grešlové Mýto, Boskovštejn, Střelice, Jevišovice, Černín, Vevčice, Rudlice, Plaveč, Výrovice, Tvořihráz, Žerotice, Prosiměřice, Práče, Lechovice, Borotice, Božice, Šanov, Hrušovany nad Jevišovkou and Jevišovka.

The largest of them is the Výrovice Reservoir with an area of 52 ha (130 acres), which is constructed directly on the Jevišovka.