It has been featured in several forms of merchandise, including figurines, plush toys, and the Pokémon Trading Card Game.

[6] In these games and their sequels, the player assumes the role of a Trainer whose goal is to capture and use the creatures' special abilities to combat other Pokémon.

Some Pokémon can transform into stronger species through a process called evolution via various means, such as exposure to specific items.

[12] According to director Junichi Masuda, there were initially concerns that Jigglypuff's cuter design would not take off with western audiences, and considerations to redesign it were made, but ultimately scrapped.

[23] During development of the film Detective Pikachu, Jigglypuff's design initially started as very fluffy, but was rejected, with The Pokémon Company stating it should look more like pigskin.

[30] Despite not being a lead character in the Pokémon franchise, game director Masahiro Sakurai selected it to appear in Super Smash Bros. due to its similarities to Kirby, which allowed the staff to reuse the model and many animations as a base for Jigglypuff.

[32][33] In the Pokémon anime series, Jigglypuff is a recurring character who aspires to be a great singer after the inspiration of Ash and company.

The Jigglypuff in Magical Pokémon Journey is spoiled and rich, living in a mansion with Wigglytuff and Squirtle, the former being her sister and the latter her butler.

Written by Megumi Hayashibara and illustrated by Kagemaru Himeno, it tells the story of a Jigglypuff who wants to make the other Pokémon happy by singing for them.

[40] In the Pokémon Adventures manga, one of the main characters, Green, has a Jigglypuff which is capable of swelling up to several times its size.

This allows Green to float with it like a hot-air balloon as well as block narrow passageways—a tactic instrumental in helping Silver and her escape the Masked Man.

[42] Jigglypuff made a cameo appearance in a season six episode of Last Week Tonight with John Oliver, in which the host accidentally kills one while playing Pokémon GO.

[58] The journal Sex Roles noted that while Jigglypuff's gender in the anime was never explicitly stated, it was identified by a majority of people as a female character in the series.

Additionally, it was the most often named "female" Pokémon by children when asked to recall one, which the study attributed to its pink color and ability to sing its opponents to sleep.

[34] Carolyn Gudmundson of GamesRadar+ disagreed, calling Jigglypuff's anime appearances "totally badass" while also criticizing its unoriginal, overused design.

[62] James Whitbrook of Gizmodo praised its appearance in the original games, highlighting its uncommon encounter rate and unique design as making it standout in comparison to other wild Pokémon.

During a 2019 tournament of Super Smash Bros. Melee, a player decided to quit due to an opponent who played Jigglypuff repeatedly stalling.

[65] Largely credited with elevating the Melee community's perception of Jigglypuff's viability in competition and setting the standard of how to play the character, a notable professional Super Smash Bros.

[66][33] In response to the controversy, the tournament Super Smash Con made some rules against “ledge-camping”, as the character is so effective with the tactic that some people considered it "game-breaking" and making the game not fun to watch.