[4] Soon after graduating from college, Mayer was commissioned to create an experimental performance for Miami Light Project's 2010 Here & Now theater festival.

[5] The result was a short satirical musical called Mrs. Ms in which Mayer attempts to marry her pet Chihuahua, only to discover that he has been unfaithful.

[11] Life and Freaky Times of Uncle Luke is a modern Miami adaptation of the 1962 French short film La Jetée, starring Luther Campbell.

The film is a told entirely through a series of installations created by Mayer, recounting Luke's rise to fame as he changes the face of hip-hop and fights for first amendment rights and later as he ushers Miami into a golden era of peace and prosperity as mayor., but everything changes when a nuclear meltdown at Turkey Point turns Miami into a radioactive wasteland filled with mutants, and Luke is the only survivor left unscathed.

[11] Mayer and Leyva eventually realized that their concept was too expensive for feature length,[14] despite being supported by Sundance's 2013 New Frontier Story Lab.

[23] Mayer's first solo show "Family Matters" opened in April 2011 at the David Castillo Gallery: a multimedia installation, it explored the "artificial worlds of '90s sitcoms"[24] through sculptures and videos, including I Am Your Grandma which would later go viral on YouTube.

[25] "Erasey Page" was an interactive exhibit Mayer created, which gave the audience a chance to "erase" a website of their choice.

[30] In 2016 Mayer debuted a series of colorful sculptures she called "Slumpies", which are specially designed for users to slump on while staring at their smartphones.

[34] In 2023, Mayer was a contestant on The Exhibit: Finding the Next Great Artist, a reality TV series that aired on MTV and the Smithsonian Channel.