She worked in the lab of Alanna Schepartz, completing a thesis on the recognition of DNA by natural transcription factors.

[6][7] Montclare has worked with the United States Department of Defense to detoxify organophosphates, which are commonly used in pesticides and as warfare agents.

[10] Instead of synthetically creating polymers, Montclare uses biologically engineered proteins that can be easily controlled by external stimuli.

[11] The She has developed a range of other nanomaterials derived from proteins, including coiled-coil fibres and helix-elastin block polymers.

[13][14] Other research in the Montclare group includes the design of protein-lipid macromolecular systems that can be used to transport nanoparticles, drugs, and genes to treat a variety of medical conditions.

[16][17] The lipid container permits transfection past a cell membrane, whilst the protein capsule can bind chemotherapeutic molecules.

[18] Montclare has been involved with outreach programs to introduce people in K-12 Education to science studies at the NYU Tandon School of Engineering.