Jo grew up playing football at school and spent his weekends working on local rice farms.
Eventually, he decided to join a Muay Thai camp near his house and continue training in his free time.
During the day, he worked at a restaurant, hotel, and fitness gym, and at night he sold whiskey on the beach for tourist parties.
[3] In the United States, Jo fought for Lion Fight, an American Muay Thai organization based in Las Vegas.
He made his ONE debut on April 20, 2018 at ONE Championship: Heroes of Honor in Manila, facing legendary kickboxer Giorgio Petrosyan.
[5] On November 9, 2018, he faced George Mann of Scotland at ONE Championship: Heart of the Lion in Singapore, where he won by unanimous decision.
[6] On February 16, 2019, Jo Nattawut would return to fight in Thailand for the first time since moving to the United States at ONE Championship: Clash of Legends in Bangkok.
[7] Jo Nattawut was selected to compete in the ONE Super Series Kickboxing Featherweight World Grand Prix, which included Yodsanklai Fairtex, Giorgio Petrosyan, and Dzhabar Askerov.
[9] In the Kickboxing Featherweight Grand Prix Semi-Finals, he was set to face Giorgio Petrosyan a second time at ONE Championship: Dreams of Gold in Bangkok.
However, in his rematch with Petrosyan, Nattawut lost by knockout in the first round, getting eliminated from the Kickboxing Featherweight World Grand Prix.
[11] After two years away, Jo Nattawut is scheduled to make his return against Yurik Davtyan in an alternate bout for the 2021 ONE Kickboxing Featherweight Grand Prix at ONE Championship: First Strike on October 15, 2021.
[14][15] He was originally set to face fellow Grand Prix alternate Dovydas Rimkus at ONE: Only the Brave on January 28, 2022.