Most of her work focuses on women's issues, queer experience, and the intersectionality of both.
Through her childhood years, she attended a Christian school for girls, which was run by nuns.
Growing up in the convent schooling system, Nesbitt came to be very familiar with religious imagery, such as the nun.
She includes nuns along with other religious themes in many of her works, such as her contribution to Menstral Taboos and an illustration in her work The Desperate Woman's Guide to Diet and Exercise that depicts a nun laying on a sofa with grapes and wine saying, "Some vows I haven't taken..."[1] Plus, Lynn Alderson wrote that Nesbitt was "responsible for the wonderful nun/whales that could be seen swimming around the walls of Sisterbite – she had a bit of a thing for nuns.
"[2] Due to the themes of feminism, queerness, and civil activism, Nesbitt's comics and illustrations often are featured as a part of larger feminist and queer works, such as Dyke Strippers, Gay Left Issue, and HERizons.