He holds the professorship for life sciences and leads the Lingner Lab[1] at the École Polytechnique Fédérale de Lausanne (EPFL).

[2] In 1993 he joined the Howard Hughes Medical Institute at University of Colorado at Boulder for postdoctoral studies under the supervision of Thomas Cech.

[4][5] The Lingner Lab studies of the structure, function and maintenance of telomeres, the nucleoprotein complexes at the ends of eukaryotic chromosomes that enable chromosome stability and that regulate cellular lifespan.

They elucidated how telomere shortening is counteracted by the telomerase enzyme that renders cancer cells immortal.

[9][10] Finally, they developed technologies to uncover the changes that occur in the telomeric proteome during aging and disease including cancer.