He made his big screen debut in 2003 with his screenplay for the Sony Pictures release Darkness Falls.

He wrote the politically themed slasher film The Tripper which featured David Arquette as writer and director.

In 2010 Oni Press released the five-issue miniseries Ghost Projekt, written by Harris and illustrated by Steve Rolston.

[3] In mid-2013, Oni Press released Harris' hardcover graphic novel Wars in Toyland, which is illustrated by Adam Pollina.

[4] In 2012, with Image Comics, Harris and artist Martin Morazzo premiered the ongoing series, Great Pacific, which ran for 18 issues.