Johannes Buchner is a German biochemist and professor at the Technische Universität München, Munich, Germany.
He performed his postdoctoral research in the lab of Ira Pastan at the National Cancer Institute of the National Institutes of Health in Bethesda, USA, before becoming assistant professor at the University of Regensburg and subsequently full professor and Chair of Biotechnology at the TUM.
[2] Buchner’s work focuses on understanding mechanisms of molecular chaperones in a quantitative and mechanistic manner.
Buchner’s work established sHsps as molecular chaperones[4] and has significantly contributed to our understanding of their function and mode of activation.
His work has provided a detailed mechanistic understanding of Hsp90 and its regulation by co-chaperones, establishing a functional chaperone cycle for Hsp90, which has become a major target in cancer therapy[7][8] Several discoveries from the Buchner lab on chaperone-mediated protein folding have been successfully translated into novel applications in biotechnology.