He was a contemporary of Josquin des Prez, and a significant composer of masses, motets, and secular music.
Little is known about his early life, but it can be inferred that he was from the south Netherlands, from archival mentions of him as being "da Piccardia" and "fiamengo".
[1] He may have been associated with the Burgundian chapel in the 1470s during the time of Charles the Bold, since he composed Je lay empris for him; however, no documentary record of his having been there has yet been found.
Ghiselin evidently returned to the Low Countries after fleeing Ferrara, for he was in Bergen op Zoom in 1507, receiving a considerable stipend at the Onze Lieve Vrouwe Gilde.
Most of his masses are based on chansons, including works by Antoine Busnois, Alexander Agricola, Guillaume Dufay, Loyset Compère, and himself.