John B. Guthrie (July 28, 1807 – August 17, 1885), a Democrat, was twice elected Mayor of Pittsburgh[1] and served from 1851 to 1853.

When Guthrie was young, his family moved from Armstrong County to Pittsburgh.

[3] Guthrie married Catherine Murray, daughter of Magnus Miller Murray, the lawyer, businessman, and two-time mayor of Pittsburgh.

[3] Guthrie served in the Mexican War with the Duquesne Grays.

During his terms, Guthrie appointed a new police force who ended the lawlessness of 1851 in Pittsburgh.