[2] After leaving the military, Biddle was appointed paymaster and Indian agent at Green Bay, Wisconsin, in 1821 and 1822.

[1] He was elected a delegate from the Territory of Michigan to the Twenty-first Congress and served from March 4, 1829, until his resignation on February 21, 1831.

[1] He was president of the convention that framed the State constitution for Michigan in 1835, even though his Whig Party was in the minority.

[3] He ran unsuccessfully as the Whig candidate[3][4] for election to the United States Senate and later for Governor of Michigan.

[2] The couple had four children that lived to adulthood:[5] In 1859, Biddle went to White Sulphur Springs in what is now West Virginia, for the summer, and died there.

After selling the Wyandotte estate, Biddle and his wife returned to Philadelphia, and later the couple spent much time in Paris.