He studied law, was admitted to the bar in 1813, and began practicing.
[3] During the Twentieth Congress, he was chairman of the U.S. House Committee on Expenditures in the State Department.
He was chairman of the Committee on Expenditures in the Department of State (Twentieth Congress).
After retiring to private life, Blair again became a member of the Tennessee House of Representatives in 1849 and 1850.
Blair died in Jonesboro, Tennessee on July 9, 1863, at age 72 years, 330 days.