John Buster

John Edmond Buster (born July 18, 1941) is an American physician who, while working at the University of California at Los Angeles School of Medicine, directed the research team that performed the first embryo transfer from one woman to another resulting in a live birth.

[4] Building upon Buster's research, over 200,000 live births resulting from donor embryo transfer have been recorded by the Centers for Disease Control(CDC)[6] in the United States.

[14] Buster's research and clinical practice in reproductive medicine include published studies in steroid physiology, pre-implantation embryology, pregnancy loss, and menopausal hormone replacement therapy.

[19] He also described for the first time the simultaneous progression of multiple androgen, progestin, and estrogen concentrations in maternal blood throughout all three trimesters of pregnancy and into the onset of labor.

[21] Buster served as lead investigator in another study demonstrating the effectiveness of an estradiol mist,[22] which has pharmacology similar to those of a trans-dermal estrogen patches.

[24] In the early 1980s, over a period of 4 years, at the University of California at Los Angeles School of Medicine,[1] Buster and his team developed a technique based on in vivo fertilization and uterine lavage – a method adapted from the commercialization of bovine embryo transfer in the cattle industry – as a means to transfer human blastocysts from fertile woman donors to ovulating or agonadal infertile recipient women.

[27] In April 2019 at the International Federation of Fertility Societies (IFFS)World Congress in Shanghai, China, Buster presented the preliminary results from the first Preimplantation Genetic Testing (PGT) using in vivo Embryos recovered by Uterine Lavage.