[3] After living firstly in Falmouth, Massachusetts Bay Colony, between 1626 and around 1635,[4] he moved ten miles north to North Yarmouth a year or so before the arrival of his compatriot William Royall (c. 1595–1676), living on a neck of land between branches of the Cousins River.
[5] In 1647, he sold approximately half of Cousins Island to Richard Bray, who settled there with William Wise.
[5][6] Conflicts forged by King Philip's War caused Cousins to abandon his Westcustogo home of over thirty years and move south.
[4] A year after Elizabeth's death at the age of around 31, Isaac remarried, to Ann Hunt.
[4] Cousins died in Cider Hill, near York, on June 26, 1682, aged 87.