Colonel The Honourable John Edmund Erskine (30 March 1662 – 13 January 1743), of Cardross, was a Scottish soldier and politician.

Erskine's strongly Presbyterian sympathies led him to choose the winning sides during the Glorious Revolution of 1688 and the deliberations prior to the Act of Union of 1707.

[10] After Jane's early death the same year he married as his second wife Anna, daughter of Sir William Dundas of Kincavel.

After Anna's death in June 1723 he married thirdly Lilias, daughter of Sir George Stirling of Keir and widow of John Murray, in 1725.

[15] After Lilias's death in March 1729, he married as his fourth wife Mary, daughter of Charles Stewart of Duncarn, in November 1729.