John Glenn Boulevard is an arterial road serving the northwestern suburbs of Syracuse, New York, mainly Liverpool, Baldwinsville, and Clay.

As currently constructed, it extends 4.11 miles (6.61 km) from Interstate 690 (I-690) in Geddes to Buckley Road in Clay entirely in Onondaga County.

Heading eastbound, the boulevard has a railroad crossing before reaching an at-grade intersection with Farrell Road roughly half a mile later.

For the remainder of the roadway, John Glenn Boulevard passes over the Onondaga Lake connector to the Seneca River/Erie Canal and has at-grade intersections with NY 370 and CR 57 (the former NY 57), in addition to a couple of apartment complex entryways, before terminating at Buckley Road (CR 46) in Clay, New York.

The arterial was originally built in the mid 1960s, connecting several newly-built suburban neighborhoods to NY 57 and the New York State Thruway.