John Jeffries II (March 23, 1796– July 1876) was an American ophthalmic surgeon who co-founded the Massachusetts Charitable Eye and Ear Infirmary in 1824 with Edward Reynolds.

[4] Jeffries resigned from this position in 1842 and had no other official interaction with the institution until his son Benjamin was named Surgeon of the Infirmary in 1867.

[1] He received a Doctor of Medicine degree from Harvard in 1819 and became a fellow of the Massachusetts Medical Society in 1826.

[1] He married in 1820, and was the father of three daughters and five sons, one of whom was Benjamin Joy Jeffries, one of the creators of the New England Ophthalmological Society.

[5][4][6] The family had a summer residence in East Boston in a neighborhood now known as Jeffries Point.