John Lawrence Karle (April 14, 1894 in Queens – 1953) was an American lawyer and politician from New York.
He graduated from Fordham Law School, was admitted to the bar in 1916, and practiced law in New York City.
In November 1925, he ran on the Republican ticket for Borough President of Queens, but was defeated by the Democrat Maurice E. Connolly.
In March 1929, Karle was appointed by Borough President George U. Harvey as Commissioner of Sewers and Borough Secretary.
In September 1929, Karle ran as the regular nominee at the Republican primary election for Queens Borough President, but was defeated by the incumbent Harvey who ran as a challenger.