At its inception, John Marshall boasted one of the few modular scheduling systems in the United States.

In the 1994-1995 school year, John Marshall High School ran a traditional eight period day offering students half-credit one-semester courses and full-credit two-semester courses.

John Marshall High School's mascot is the Monarch.

It has athletic programs in football, basketball, bowling, baseball, soccer, swimming, volleyball, tennis, hockey, cross country, track and field, golf, wrestling, cheerleading, and lacrosse.

John Marshall competes in the Ohio Valley Athletic Conference.