St. Clairsville High School is a public high school in St. Clairsville, Ohio, United States.

It currently houses grades 9 through 12.

Their nickname is the Red Devils, and they compete in the Ohio High School Athletic Association as a member of the Buckeye 8 Athletic League as well as the Ohio Valley Athletic Conference.

The Red Devil Football team went to the State Finals in 2012 and lost, 46-36, to Clinton-Massie.

In 2016, the Red Devil boys track & field team won the school's first-ever OHSAA state title, narrowly defeating Lexington, 33-31.