Martins Ferry High School is a public high school in Martins Ferry, Ohio, United States.

Athletic teams compete as the Martins Ferry Purple Riders in the Ohio High School Athletic Association as a member of the Buckeye 8 Athletic League as well as the Ohio Valley Athletic Conference.

The Martins Ferry City School District has median household income of $23,960, thus making the school eligible for a Title I program, including access to state and federal assistance to help low-income and at risk students.

The head school administrator, Joe Mamone, oversees the school's staff, including thirty full-time "equivalent" teachers serving the student body with an average class size of 17.8.

The majority of students enrolled are White, making up about eighty-three percent of all students.