Originally an actor and playwright, he was a senior editor at Amazon.com, starting their electronic greeting card service and editing their toys site.
His musical, The Big Time, co-written with Chris Ballew of The Presidents of the United States of America, was performed at the Edinburgh Festival Fringe.
Moe was hired at KUOW, Seattle's NPR station, in 2001 as a staff writer for Rewind, a national news and satire show hosted by Weekend America's Bill Radke.
[8] On September 10, 2012, Moe left Marketplace Tech Report to devote his full-time attention to hosting the radio variety show Wits.
The book is a compilation of fictitious letters, notes, and messages based around familiar songs, movies, TV shows, and sporting events.
He is also the author of Conservatize Me: How I Tried to Become a Righty with the Help of Richard Nixon, Sean Hannity, Toby Keith, and Beef Jerky, published in October 2006.
In June 2015, Moe along with rapper Open Mike Eagle launched Conversation Parade, a podcast in which the two discuss the Cartoon Network animated series Adventure Time.
[10] In 2016, Dr. Craig Bowron MD FACP, contributor at Huffington Post, wrote an article announcing and recommending a new podcast by John Moe, The Hilarious World of Depression.
It follows a similar format to the previous show and again focuses on long-form interviews, often with creative artists and public figures telling stories of their own mental health struggles.
The show's episode with actor Joel Kim Booster talking about his active depression led to an LA Press Club award.