The Hilarious World of Depression (often abbreviated as THWoD) was a biweekly comedy interview podcast distributed by American Public Media and hosted by the writer and public radio host John Moe.

The podcast was supported by grant funding from HealthPartners and "Make it OK," a campaign to reduce the stigma of mental illness.

[2] John Moe announced that he would be hosting a new podcast, Depresh Mode with John Moe, which is on the Maximum Fun website,[3] and would cover additional mental health issues as well.

"[6] Dr. Craig Bowron, in HuffPost, writes that he would "even prescribe it for folks who are not dealing with depression.

"[8] USA Today named it their weekly Podcast Pick in December 2016, calling the interviews "frank and often funny.