On leaving College, he commenced the study of law; but soon after, having married Miss Louisa Rembert, the daughter of a wealthy planter in Georgia, he turned his attention to cotton planting, and settled near Huntsville, Alabama.
He served several terms in the Alabama State Legislature, where he distinguished himself as the champion of a liberal system of internal improvements.
His services in this department, and in the development of the great Mississippi River valley, were recognized at the "Internal Improvement Convention," which met at Memphis, in 1835, and of which John C. Calhoun was President, when Mr. Pope was made Chairman of the Committee on Agriculture.
For some years before his death he was President of the Union Bank of Tennessee and was prominently engaged in the Memphis and Charleston Railroad enterprise.
In 1837, he lost his first wife, and a few years later married Miss Elizabeth Hemphill Jones, of Wilmington, Delaware, whom he also survived.