John Pye-Smith FRS FGS (25 May 1774 – 5 February 1851) was a Congregational minister, theologian and tutor, associated with reconciling geological sciences with the Bible, repealing the Corn Laws and abolishing slavery.

The son of a Sheffield bookseller, Pye-Smith was surrounded by books in his youth and was practically self-taught: he did take Latin lessons from Jehoiada Brewer.

During the politically turbulent 1790s, Pye-Smith took over the editorship of the Sheffield Iris, the leading abolitionist newspaper in the North of England, during the imprisonment of its editor, his friend James Montgomery.

Pye-Smith was the theological tutor at the Dissenting academy known as Homerton College near Hackney, London for forty-five years between 1805 and 1850.

John Pye Smith died in Hackney in 1851 and is buried below a marble chest tomb monument in Dr Watts' Walk, at the Congregationalists' non-denominational garden cemetery in the grounds of Abney Park, Stoke Newington, north London.