The plans from Kaleida Health included moving the children's hospital to the downtown Buffalo Niagara Medical Campus to better consolidate their facilities.

[15] Residents of Buffalo did not support the planned move and launched a campaign against the movement and Kaleida Health called "save our children's hospital," which included many celebrities from Buffalo including Jim Kelly and Pat LaFontaine.

[18][19] The hospital was built by Turner Construction[20] and designed by the acclaimed architectural firm, Shepley Bulfinch.

[26][27][28] Also in the wake of the 2020 COVID-19 pandemic, the hospital added ICU beds and placed NICU patients in the same room as their mother.

[29] Buffalo Bills quarterback Josh Allen has done charity work with Oishei Children's Hospital.

[30][31] In response, fans of the Buffalo Bills (colloquially known as 'Bills Mafia') began to donate to Oishei Children's Hospital in $17 increments (17 being Allen's jersey number).

[40][41] The hospital has an American Academy of Pediatrics level III neonatal intensive care unit with a capacity of 64 beds for critically ill newborn babies.

Bass reached a settlement with the state medical board and pleaded no contest and was put on probation.