A sequel to the novels, the game takes place several years after the sixth book, and continues the story of Oliver Metcalf, his family, and the town of Blackstone.

Exploring the mansion, Oliver encounters several spirits of patients who are bound to the asylum by their possessions, including a teenage girl with hysterical pregnancy, a schizophrenic who believes she's English royalty, and a depressed woman who was treated with steam baths and hydrotherapy.

Disheartened by the failure of traditional medicine, Oliver's father gradually turned to more and more extreme methods, including totally dismembering and vivisecting an 8-year-old boy to cure his illness.

Over the course of the game, Oliver collects several personal items that influence him, causing him to nearly kill himself in several psychiatric methods (ECT, self-injecting neuro-toxins, locking himself in a steam box).

[3] In Computer Gaming World, Allen Greenberg summarized, "Blackstone Chronicles is definitely a unique piece of work with a gripping storyline, wonderful graphics, and a most talented cast.

While he disliked its visuals and lack of character interaction, he felt that Blackstone Chronicles offered "enough to recommend it to many adventure-starved gamers.