The game is set in the post-apocalyptic New Jersey-New York-Pennsylvania Tri-state area, where the player controls a team of off-beat and often useless superheroes who battle a number of strange enemies, most notably the evil Dr. Entropy, a human jack-in-the-box with plans to bring chaos in the world.

Due to designer Steve Meretzky's heavy freelance workload during development of Superhero League of Hoboken, he contracted a friend to help with the game's programming in the last months of 1993.

[7] Two month later in the October issue, Scorpia wrote, "[Superhero League of Hoboken] is lightweight fare, and as such, may disappoint those looking for challenging puzzles.

"[5] In the October 1994 edition of PC Gamer UK (Issue 11), James Leach summarized Superhero League of Hoboken as "good", but he believed that those who "don't like the surrealism ... will soon get bored.

Its unique characters, captivating missions, overarching story line, and engaging details of play result in a satisfying sense of role-playing.

The editors remarked that Superhero League of Hoboken "broke most of the rules", and that its "goofy dialogue and storyline, and well-balanced gameplay, make for a wild ride through designer Steve Meretzky's left-of-center imagination.