He served in the Pennsylvania Provincial Assembly, then a unicameral legislature, representing Chester County from 1767 to 1771.
[1] He was appointed surveyor by the governor to run a line from Schuylkill to Lancaster to prepare for the Strasburg Road.
He was also involved in the Schuylkill-Susquehanna canal study of 1783 and the boundary commission for the newly created Delaware County in 1789.
[2][5] He was appointed one of the Boston Port Bill Committee and was a deputy in the first Provincial Conference of Representatives at Philadelphia on July 14, 1774.
These activities on behalf of the Revolution and particularly Sellers' role in signing the Continental currency led to his disownment by the Society of Friends.