[1][2][3] The route started at the "second ferry" on the Schuylkill River, today's Market Street in Philadelphia, and went through West Chester, East Fallowfield Township, and Gap, before ending in Strasburg.
[4] Earlier roads travelled much the same route, including a Native American path in use as early as 1620.
[5] The use of wagons on this road began as early as 1714 as it developed out of the earlier Great Minquas Path.
There it continued east via Atglen, Parkesburg, Mortonville, and West Chester, crossed into Delaware County and there led through Lima and Rose Valley, where it could go south to Chester or east to Darby, and finally to Philadelphia.
Due to the commercial use of Strasburg Road during the Colonial and Early Federal periods, at least twenty-three buildings or historic districts along the road have been listed on the National Register of Historic Places in Chester County.