Sir John Sherlock (1603-1652) was an Irish landowner, politician and courtier of the seventeenth century.
He was probably born at Littlerath, near Sallins, County Kildare, eldest son of the wealthy merchant Christopher Sherlock and his first wife Eleanor.
The Sherlock family had settled in County Kildare early in the previous century.
He appears to have enjoyed the favour of King Charles I of England: he was knighted in 1635 and became a gentleman of the Privy Chamber.
His second wife, whom he married in 1634, was Katherine Ashburnham, who outlived him and remarried John Preston, who had been Mayor of Dublin 1653–4, and later sat in the Commons for Navan in 1660.