The game focuses on Marvel Comics characters facing a new team of super villains known as The Imperfects.

A sequel, Marvel Chaos, was announced in 2007, and was to be developed by EA Chicago for PlayStation 3 and Xbox 360, but was cancelled the following year.

Combat is simplified in favor of allowing the player greater movement, and the game initially drew comparisons to Power Stone, Super Smash Bros. and Ehrgeiz as a result.

The game featured Fatality-like finishing moves that could be triggered as soon as an opponent's health falls to 25% or lower.

This releases him from the control of Niles Van Roekel, who lets his Imperfects into the city to fight heroes.

These include 10 existing Marvel characters—two of which differ between the PlayStation Portable version and other versions—and the eight members of the Imperfects, marked below in italics.

In addition to the playable characters, Hulk and the Punisher make brief cameo appearances in the console versions as victims of the invading Imperfects.

[19] Many complaints about the game revolved around the fact that AI opponents would chain-abuse projectile special moves, dealing significant damage to a player character, with the AI character immediately triggering the fatality upon dropping the player to low health.