The school, originally situated on Main Street in downtown Johnson City, was relocated to where it currently stands on Reynolds Road.[when?]

The Johnson City Guidance Office asserts that the "Johnson City Senior High School provides a comprehensive program in curricular, co-curricular and extracurricular activities designed to permit the development of programs that enable pupils to identify their talents, skills, strengths, and special interests."

After facing flooding in 2006 and again in 2011, the Johnson City High School football field located at Greensfield (aka Northside Park) was left in a dilapidated state, as the eight feet of standing water heavily ruined the bleachers, scoreboard, concession stand, restrooms, and team rooms.

The varsity football team played their home games at Binghamton High School's Alumni Stadium from 2011 to 2013.

The grand opening of the new 'Wildcat Stadium' was held in 2014 which was ultimately fitted with bleachers, restrooms, a concession stand, and team rooms.