[1] The team was affiliated with the St. Louis Cardinals organization from 1975 through 2020 and played in the Rookie-level Appalachian League.

They played their home games at TVA Credit Union Ballpark.

The start of the 2020 season was postponed due to the COVID-19 pandemic before ultimately being cancelled on June 30.

[5][6] In 1955, Johnson City and the Salem Rebels were declared co-champions of the Appalachian League when their final playoff series was canceled due to rain.

[9] Many of the players fielded by Johnson City have gone on to distinguish themselves in Major League Baseball.