He was a leading figure in the study of perception, selective attention and multisensory integration in the normal and damaged human brain.

From 2004 - 2009 he was Director of the UCL Institute of Cognitive Neuroscience, an interdisciplinary research centre that studies mental processes in the human brain.

[5] Driver's research focused on selective attention, spatial cognition and multisensory integration (the interplay between our different senses) in the healthy and damaged human brain (e.g. in hemispatial neglect).

He used an integrative methodological approach combining psychophysical, neuropsychological, neuroimaging and TMS, and was one of the first to perform concurrent TMS-fMRI[6] to study how dynamic interactions between brain regions can support cognitive functions.

He took his own life in London on 28 November 2011, aged 49, ten months after shattering his knee in a motorcycle accident which left him in debilitating chronic pain.