He completed his DPhil in the Department of Statistics at the University of Oxford supervised by Professor Brian Ripley (1998–2002).

In 2007 he became an affiliated group leader at the Wellcome Trust Center of Human Genetics[11] at the University of Oxford.

He has worked on haplotype estimation,[15][16][17][18] genotype imputation,[19] genotype calling from arrays and sequencing, sparse tensor decomposition for RNA-seq datasets,[20] population structure,[21] phenotype prediction and mixed models,[22] gene–gene interactions[23] and brain imaging genetics.

His research group was responsible for the haplotype estimation and genotype imputation for the UK Biobank dataset.

[25] He has been an ISI Highly Cited Researcher from 2014-2018[26] He has acted as an expert witness in a patent trial[27] In 2012 he was awarded a Philip Leverhulme Prize[28] for "leading the way by constructing powerful and ingenious novel statistical methodology for population and medical genetics, together with associated fast computational algorithms and software."