He was born between Susan Powell Mason and John Collins Warren, on February 5, 1811, in the house located at the No.

He studied alongside other American students such as Henry Ingersoll Bowditch, Oliver Wendel Holmes and Robert William Hooper, who were also seeking medical education in the region.

[6] He visited many notable doctors at the time, including: Astley Cooper, Charles Bell, James Syme and Robert Liston in the United Kingdom, Guillaume Dupuytren, Philibert Joseph Roux, Jacques Lisfranc and Pierre Charles Alexandre Louis in France.

[8][13] On May 6, 1853, while returning from a meeting of the American Medical Association in New York, he was a passenger on the train which met with the Norwalk rail accident.

[14] However, other several members of the association, including William Cecil Dwight and Abel Lawrence Peirson, who were in the same car as the one Warren was in,[15] were killed.