He played in Major League Baseball (MLB) for the San Diego Padres, Boston Red Sox, and New York Yankees.

Layne attended Fort Zumwalt South High School in St. Peters, Missouri, where he played baseball and soccer.

Layne progressed steadily up the minor league ladder over five seasons in the Diamondbacks' system and was promoted to the Triple-A Reno Aces in early 2011.

[4] Layne made 5 starts and notched a 7.77 ERA for the Triple-A Tucson Padres before he was demoted to the Double-A San Antonio Missions and began working out of the bullpen.

Layne was noted as having a "rubber arm" and he enjoyed having the chance to pitch every day, so he welcomed the transition to a reliever role.

[6] Layne made his Major League debut the same night against the Atlanta Braves, striking out the side in his one inning.

Layne earned his first win as a Major Leaguer on September 4 when he struck out Adrián González, Matt Kemp, and Hanley Ramírez in order in the 10th inning.

[14] Layne signed a minor league contract to return to the Boston Red Sox on February 24, 2018.