Orange continued his research stemming from his graduate studies and developed a novel therapy that bypasses the natural killer cell defect.
As a result of his contributions to research and treatment of inherited immune deficiency diseases, Orange received the 2009 American Philosophical Society Judson Daland Prize.
[2] The following year, he collaborated with German researcher Christoph Klein to perform cell imaging and analysis on children diagnosed with WAS soon after birth.
[5] Orange eventually left the University of Pennsylvania in 2012 to join the faculty at Baylor College of Medicine (BCM) and serve as chief of Immunology, Allergy and Rheumatology and director of the Center for Human Immunobiology at Texas Children's Hospital.
[6] He remained in Houston until 2018 when he joined the faculty at Columbia University Vagelos College of Physicians and Surgeons as their chair of pediatrics and pediatrician-in-chief at Morgan Stanley Children's Hospital.