José Luis Cisnero (born April 11, 1989) is a Dominican-American professional baseball relief pitcher who is a free agent.

In parts of two seasons for the Astros, he made 33 relief appearances, posting a 4.66 ERA with 46 strikeouts in 48+1⁄3 innings.

[4] He made 4 appearances for the Double–A Pensacola Blue Wahoos in 2015, recording a 3.38 ERA with 6 strikeouts over 5+1⁄3 innings pitched.

On November 9, 2018, the Detroit Tigers signed Cisnero to a minor league contract with an invitation to spring training.

With the 2020 Detroit Tigers, Cisnero appeared in 29 games, compiling a 3–3 record with a 3.03 ERA and 34 strikeouts in 29+2⁄3 innings pitched.

In 2021, Cisnero made 67 relief appearances, posting a 4–4 record, 4 saves, and a 3.65 ERA, with 62 strikeouts in 61+2⁄3 innings.

On March 23, 2022, the Tigers and Cisnero agreed on a one-year contract worth $1.9 million, avoiding arbitration.

[14] Cisnero pitched in 28 games for the 2022 Tigers, all in middle relief, posting a 1.08 ERA and 23 strikeouts in 25 innings.

On January 13, 2023, Cisnero agreed to a one-year, $2.2875 million contract with the Tigers, avoiding salary arbitration.