José Gregorio Salazar y Castro (1773 – 1 February 1838)[1] was a general and a Liberal politician in Central America.

He was acting president of the Federal Republic of Central America from September 16, 1834 to February 14, 1835, in between two administrations of Francisco Morazán.

Their son, General Carlos Salazar, served briefly as provisional president of the state of El Salvador, from June 23 to July 13, 1834.

José Gregorio Salazar (the father) ruled the state as provisional chief from that date to September 30, 1834.

His troops, mountain dwellers from Mataquescuintla, ran wild in the city, committing many kinds of depredations.